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Ayara, First of Locthwain Combos

Ayara, First of Locthwain + Plague of Vermin

Ayara, First of Locthwain Plague of Vermin

Combo result
Drain the table of all their life (if you have the highest life total at the table).
Prerequisites

Ayara, First of Locthwain on the battlefield. Plague of Vermin in hand, and available to cast it. Have the highest life total at the table.

Acererak the Archlich + Ayara, First of Locthwain + Bontu's Monument

Acererak the Archlich Ayara, First of Locthwain Bontu's Monument

Combo result
Near-infinite ETB. Near-Infinite LTB. Near-Infinite ventures into the dungeon. Near-Infinite life loss. Near-Infinite lifegain. Near-Infinite scry. Near-Infinite treasure tokens. Infinite card draw. Near-Infinite creature tokens. Near-Infinite storm count.
Prerequisites

Acererak in hand. All other permanents on the battlefield. You have not completed Tomb of Annihilation. You have at least 3 life.

Ayara, First of Locthwain + Carnival of Souls + Gravecrawler

Ayara, First of Locthwain Carnival of Souls Gravecrawler

Combo result
Infinite life loss, Infinite lifegain. Infinite sacrifice triggers. Infinite ETB. Infinite LTB.
Prerequisites

All permanents on the battlefield. {B} available.

Ayara, First of Locthwain + Tree of Perdition + Dollhouse of Horrors

Ayara, First of Locthwain Tree of Perdition Dollhouse of Horrors

Combo result
Target opponent loses the game. Near-infinite lifeloss for target opponent.
Prerequisites

Tree of Perdition in your graveyard. All other permanents on the battlefield. You do not control a Construct. available.

Ayara, First of Locthwain + Tree of Perdition + Offspring's Revenge

Ayara, First of Locthwain Tree of Perdition Offspring's Revenge

Combo result
Target opponent loses the game. Near-infinite lifeloss for target opponent.
Prerequisites

Tree of Perdition in your graveyard. All other permanents on the battlefield. available.

Gravecrawler + Phyrexian Altar + Ayara, First of Locthwain

Gravecrawler Phyrexian Altar Ayara, First of Locthwain

Combo result
Infinite life loss. Infinite lifegain. Infinite ETB. Infinite LTB. Infinite death triggers. Infinite sacrifice triggers.
Prerequisites

All permanents on the battlefield plus an additional zombie.

K'rrik, Son of Yawgmoth + Ayara, First of Locthwain + Carrion Feeder

K'rrik, Son of Yawgmoth Ayara, First of Locthwain Carrion Feeder

Combo result
Infinite ETB. Infinite LTB. Infinite death triggers. Infinite sacrifice triggers. Infinite storm count. Infinite life loss. Infinite life.
Prerequisites

All permanents on the battlefield.

K'rrik, Son of Yawgmoth + Ayara, First of Locthwain + Cloudstone Curio

K'rrik, Son of Yawgmoth Ayara, First of Locthwain Cloudstone Curio

Combo result
Infinite damage. Infinite +1/+1 coutners on K'rrik. Infinite ETB. Infinite LTB. Infinite lifegain. Infinite lifegain triggers. Infinite lifeloss. Infinite storm count.
Prerequisites

All permanents on the battlefield. Your life total is at least ten. You have a creature card in hand with mana cost {B}.

Marrow-Gnawer + Thornbite Staff + Ayara, First of Locthwain

Marrow-Gnawer Thornbite Staff Ayara, First of Locthwain

Combo result
Infinite creature tokens. Infinite ETB. Infinite LTB. Infinite sacrifice triggers. Infinite life. Infinite life loss.
Prerequisites

All permanents on the battlefield. Thornbite Staff equipped to Marrow-Gnawer. Marrow-Gnawer is not summoning sick. At least 2 other rats on the battlefield under your control.

Yawgmoth, Thran Physician + Mikaeus, the Unhallowed + Ayara, First of Locthwain

Yawgmoth, Thran Physician Mikaeus, the Unhallowed Ayara, First of Locthwain

Combo result
Infinite card draw. Infinite draw triggers. Near-infinite ETB. Near-infinite LTB. Near-infinite death triggers. Near-infinite sacrifice triggers. Near-infinite lifegain. Near-infinite lifegain triggers. Near-infinite lifeloss.
Prerequisites

All permanents on the battlefield. Your life total is at least two. You control at least one additional nontoken non-Human creature with toughness two or greater.